Kinases, key drivers of malignant transformation and major contributors to a
variety of other human pathologies, have emerged as some of the most exciting
targets in drug discovery. However, with initial well documented success stories
came realization that many hurdles lie in the path of successful development of
new drugs, targeting kinase signaling. GTC’s 2nd Protein Kinases & Drug
Design Conference, to be held in October 24-25, 2013, San Diego, CA, will bring together
speakers representing world leading academic centers and pharmaceutical
companies to discuss how to overcome the many hurdles and answer exciting key
questions. Experts will also share their positive and negative experiences
on how predictive preclinical models are with clinical efficacy and toxicology.
Key Questions to be Discussed:
- What are the best approaches to identify key kinases
contributing to neurodegenerative diseases and major forms of human cancer
from leukemias and breast cancer to malignant gliomas?
- How do different factors, including genetic background,
interactions with stroma, “stemness” of the tumor cells contribute to tumor
responses to kinase inhibitors?
- What are the best computational, chemical biology and
structural biology approaches to de novo kinase drug design, including a
“holy grail” of kinase drug discovery - non-ATP competitive inhibitors?
- What is the right balance between inhibitor selectivity
- Are covalent inhibitors a “no-no” in drug discovery?
- What have we learned from the use of the latest
generation of inhibitors, targeting many of the hottest pathways (PI3K,
Her2, CDKs, JNK) in pre-clinical models and clinical trials?
- How can we predict pharmacological properties of new
Sessions for 2013 Agenda:
I. Advancements in Target Identification
II. Novel Advances in Kinase Drug Design
III. Identification of Selective Kinase Inhibitors
IV. Lessons From Preclinical Model & Clinical Development
This conference is part of our Protein
Discovery Summit 2013, which
consists of a pre-conference workshop and three other parallel conferences shown below.
Discovery Summit 2013:
Pre-Conference Workshop: In-Silico Protein Docking
Conference: Protein Kinases & Drug Design
Antibody & Protein Therapeutics
Protein Expression, Purification & Characterization