4rd Biobased Chemicals Commercialization & Partnering
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Overview | Speakers | Agenda | Poster Submissions | Venue | Sponsors
THE 2014 PROGRAM IS IN PRODUCTION, BELOW IS 2013'S AGENDA.
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Day 1 Day 2
Day 1 - Monday, September 16, 2013
7:00 Registration & Continental Breakfast
7:55 Welcome & Opening Remarks
Moderator: Randy Cortright, Executive Vice President, Founder & Chief Technology Officer, Virent
KEYNOTE PRESENTATION
8:00 Toward a New Generation of Renewable Fuels and Chemicals

John P. Ranieri


Todd Werpy
Vice President, Research & Development
ADM
As one of the world's largest agricultural processors, Archer Daniels Midland Company connects the harvest to the home to meet the vital food and energy needs of a growing global population. The same operations that enable ADM to produce hundreds of food ingredients from farmers’ crops also provide it with the scale and expertise to efficiently produce renewable fuels and chemicals. The company is a leading producer of corn ethanol and biodiesel, and in recent years, it has also formed strategic alliances with academic, industry and government partners aimed at developing a new generation of advanced biofuels made from lower-value agricultural resources, including the stalks, cobs and leaves that remain on corn farmers' fields after harvest. At the same time, ADM has been working to broaden its portfolio of alternatives to petroleum-based chemicals and industrial products. In this presentation, Dr. Todd A. Werpy, ADM Vice President Research & Development, will offer an overview of the company’s biofuel research partnerships, discuss some of the pilot projects under way, and describe ADM’s efforts to develop both direct, drop-in replacements for commonly used chemicals as well as novel chemicals made from bioadvantaged molecules.
Novel Technologies & Platforms in Bio-Based Chemical Production
Moderator: Randy Cortright, Executive Vice President, Founder & Chief Technology Officer, Virent
8:45 What Shale Gas Means for Bio-Based Chemicals and Materials
Mark Bunger, Research Director, Lux Research
The emergence of shale gas as a disruptive factor in the global energy and chemicals landscape is clear. What’s NOT clear, however, is who will benefit or suffer, and how. While some are already declaring energy independence, the technologies for converting dispersed methane sources are still evolving, and they each address different markets ranging from chemicals to transportation fuels or electrical power. Drawing on Lux Research’s evaluations of related companies, partnerships, and investments in agriculture, synthetic biology, and bio-based chemicals, Research Director Mark Bünger will describe how this space is likely to evolve, and where corporations, investors, and policymakers should focus.
9:10 Scale-Up and Commercialization of Bio-Based Adipic Acid and HMD
Tom Boussie, Vice President, Corporate Development, Rennovia
Rennovia is a private company based in Menlo Park, CA developing chemical catalytic process technologies for cost-advantaged production of existing petrochemical products from bio-based feedstocks. Rennovia has developed processes for the production of adipic acid (AA) and hexamethylenediamine (HMD) from sugars. Rennovia’s process technology offers significant production cost advantage over conventional petro-based technologies, and as well provides a greatly reduced carbon footprint and other environmental benefits. Rennovia’s bio-based AA and HMD products have wide application in polyurethanes, polyesters, and non-phthalate plasticizers, and together enable for the first time production of 100% bio-based nylon-6,6.

This presentation will describe:
- Rennovia’s approach to renewable chemicals production, including AA and HMD
- Projected cost advantage of bio-based AA and HMD over petro-based products
- Environmental benefits of Rennovia vs. petro-based AA and HMD production
- Current status of AA and HMD technology development
- Scale-up and commercialization pathways for both products
9:35 Developing the Value Chain to Advance New Levulinic Ketals and Levulinic Derivatives
Atul Thakrar, President & Chief Executive Officer, Segetis
Levulinic acid and levulinate esters are readily derived from cellulose, hemi-cellulose, or starch feedstocks. The discovery of highly selective ketalization of alkyl levulinates is enabling the development of novel bio-derived monomers and derivatives with wide-ranging applications. Levulinic ketal esters bring many unique and desirable traits to polymer-based products; for example, when compounded in PVC, they bring efficient plasticization with low migration. Incorporated in liquid formulations, they bring broad solvency and excellent solvent coupling. This talk will focus on Segetis’ efforts to commercialize this versatile levulinic ketal platform and stimulate the LA value chain.

Benefits:
1. Commercialization of new technology
2. Partnering across the value chain
3. Renewable chemistry from thermochemical conversion processes
4. Scale-up of new processes for economies of scale
10:00 Morning Networking Break
10:30 Creating the Bio Refinery of the Future
Tjerk de Ruiter, President & Chief Executive Officer, LS9
Using Natures Advantaged Fatty Acid Metabolism: LS9’s Passion is to catalyze a Rapid and Widespread transition to Renewables. To make this happen, we use natures Advantaged Fatty Acid Metabolism and combine it with novel Biosynthetic Pathways to create a library of product specific biocatalysts. This technology allow us to control chain length, branching, saturation and chemical groups to produce a wide range of product families, all in a single cell. This platform enables the production of a wide range of products from vehicle-ready fuels to chemicals for lubricants, detergents and personal care. With feed stock flexibility and all products using the same simple manufacturing process, LS9 creates the Bio refinery of the future.

LS9 Creates the Bio Refinery of the Future
- Provides diversity
- Feedstock flexible
- Simple scalable process
- Attractive markets
10:55 The Use of Waste Methane for the Production of a Novel, Biodegradable, Biobased Plastic
Anne Schauer-Gimenez, Director of Biological Research, Mango Materials
Mango Materials uses waste methane gas (biogas) as a feedstock to produce pellets of polyhydroxyalkanoate (PHA), a valuable polymer that is converted into a variety of high margin or high volume, eco-friendly plastic products such as childrens toys, electronic casings, water bottles, and packaging containers. The current plastics market is dominated by petroleum-derived, non-biodegradable, energy-intensive plastics, which often persist in the environment upon disposal. Alternative plastics are derived from rapidly renewable biological resources (biobased) and consumed by microbes when no longer needed (biodegradable). Unfortunately, these alternative plastics are often costly to produce and their manufacturing process requires significant amounts of energy. Mango Materials has a novel, patented, energy-efficient method to produce a biodegradable, biobased polymer at a price competitive with petrochemical-based polymers.

The broader impact of this project will ultimately be the widespread production of low-cost bioplastics from waste biogas and the eventual displacement of petroleum-based plastics. When products made from Mango Materials bioplastic are disposed in modern wastewater treatment plants or landfills, they biodegrade anaerobically (without oxygen) to methane. This methane can be cycled back and re-enter the process as feedstock to produce more PHA. Thus, the life cycle may be closed, creating a cradle to cradle system. This use of biogas will provide a strong economic incentive for facilities to capture their methane, rather than releasing or flaring it, which will reduce greenhouse-gas emissions and reduce corresponding impacts on global warming.

Benefits of the talk include:
• Update on the current and future status of bioplastics industry as a whole
• Learning about a new method for an affordable production of bioplastics
• Alternative, economically-advantageous uses for methane (greenhouse gas)
• End of life options for bioplastics
11:20 Cost Competitive Production of C2 and C3 Compounds from the ZeaChem Process
Bryan Yeh, Executive Vice President, Technology, Zeachem
The market for 2 carbon (C2) and 3 carbon (c3) molecules such as acetic acid and propionic acid are worth $485 and $595 billion respectively. The key to penetrating these markets is to offer a fungible product that can be produced at costs below those made with petroleum feedstock yet offer the attribute of being renewable. ZeaChem has developed a cellulosic biochemical process that has a 40-50% higher yield than other processes, yet leverages mature technology to enable commercialization with favorable economics. In February, 2013, ZeaChem produced cellulosic ethanol from its demonstration facility in Boardman, Oregon. The same process also produced cellulosic acetic acid as well as cellulosic ethyl acetate.

This presentation will highlight:
• ZeaChem’s process
• ZeaChem’s technology differentiators
• Pictures from the demonstration site
• State of Technology
End User Applications & Opportunities for Biobased Chemicals
Moderator: John Monks, Vice President, Business Development, Rivertop Renewables
11:45 Biobased Chemicals: The Path to Commercialization
Rick Eno, President & Chief Executive Officer, Metabolix
Metabolix is a leading industrial biotechnology company and pioneer in the development of biobased plastics and chemicals, combining its expertise in bioscience with innovative engineering excellence to address global markets. The Metabolix scientific foundation and core science is the metabolic pathways for the production of a class of microbial biopolymers – polyhydroxyalkanoates (PHAs) – from renewable resources. PHAs can be tailored through metabolic pathway engineering and have a wide range of applications in industry, including use in polymer form as biobased plastics or in monomer form as chemical intermediates.

Metabolix is also focused on developing four-carbon (C4) and three-carbon (C3) chemicals produced from biobased, renewable feedstocks. The C4 program is currently at the semiworks scale (80,000L) and Metabolix has shipped samples of biobased gamma butrylactone (GBL) to prospective customers for testing, working towards partnerships to bring biobased C4 industrial chemicals to commercial production. Metabolix is making steady progress with its C3 program as well – the Company is currently running fermentation at the 20L scale and recently successfully recovered acrylic acid from biomass using its proprietary FAST process. In 2013, Metabolix plans to continue fermentation scale up, engineering of microbial strains, and development and optimization of its FAST recovery technology to produce biobased C4 and C3 chemicals to match chemical industry specifications for quality and purity.

This presentation will outline the Company’s experience developing biobased competitive replacements for petroleum-based industrial chemicals, and the path to commercialization.

Talk Benefits:
- Hear from a leading industry expert about the challenges to and advantages of commercializing a biobased product in a market dominated by petrochemicals.
- Details the advantages a biobased process provides beyond the environmental benefits.
12:10 Lunch Provided by GTC
1:40 Biomaterials in High Gear
Karl Sanford, Vice President, Technology Development, Genencor and Research Fellow, Dupont
This presentation will describe progress in the development of biomaterial based opportunities at DuPont and the use of collaboration as a central strategic theme. New materials are difficult to commercialize for a variety of reasons but matching technology readiness to market place receptivity and customer need is critical. The Bio-PDO® story with the resultant development of the Sorona® polymer platform has taken almost twenty years to reach several hundred million dollars in revenue. Collaborations in technology, manufacturing and commercialization were required for success and this story is illustrative of the importance of inclusive innovation as a way to surmount the hurdles and get to the market place. Building from this beginning, DuPont is using its rich technology capabilities in chemistry, biology and materials science sciences to generate a product pipeline in the biomaterials space that spans large volume drop-ins to advanced materials. Although investment intensity is high and long commercialization timelines exist, the design and manufacture of advanced materials offer attractive growth opportunities. The development of advanced materials is of national importance and provides industrial biotechnology a new innovation space to add value particularly through the use of synthetic biology as manufacturing paradigm.

Benefits:
Update on Sorona®;
approaches to inclusive innovation;
new product pipeline;
nanobiotechnology
2:05 Biorefinery Strategies for Optimizing Value for Agriculturally Derived Feedstocks
William Orts, Research Leader, Bioproduct Chemistry & Engineering, USDA, Agricultural Research Service, Western Regional Research Center
The goal of the USDA Biorefining group is to work with the industry to enable new, commercially-preferred technologies for conversion of agricultural materials to fuels, value-added co-products and other biobased products. The research team based in Albany, California is developing biorefinery strategies relevant to the Western US with emphasis on development of (1) biomass feedstocks prevalent in the West, (2) new value-added chemicals, (3) composites and nanocomposites, and (4) biopolymers. Recent work has revolved around development of the "Generation 1.5 Biorefinery" in which processes are combined to provide fermentative production of marketable products from both sugar/starch feedstocks and its associated plant fiber (grain fiber, stover, bagasse, etc.) wastes within the same facility. Such facilities can utilize sugar sources, agricultural-waste and/or food-processing wastes to produce value-added products including C2 alcohols, ketones, aldehydes, carboxylic acids, aromatics, as well as specialty co-products such as xylitol, sorbitol mannitol, eugenol, and isosorbide.
2:30 BioFene™ as a Feedstock for Chemicals, Polymers, and Plastic Additives
Susan Schofer, Scientist, Amyris
2:55 Creating New Market Opportunities for Renewable Chemicals
Jeff Goodman, Chief, Environmental Management Division, USDA
The BioPreferred program was created by Congress to stimulate markets for new and emerging biobased products through a mandatory Federal procurement requirement and the creation of a consumer-facing USDA Certified Biobased Product label. Renewable chemicals can be one of the biggest uses of the label and will benefit from being recognized by USDA.
3:20 Afternoon Networking Break
Securing Funding & Strategic Partnerships
Moderator: William Baum, Executive Chairman & Chief Business Development Officer, Genomatica
3:50 PROESA™ - Cost Effective Sugars for the Production of Fuels and Chemicals from Biomass
Kevin Gray, Vice President, Biobased Chemicals, Chemtex; Beta Renewables
Since 2006 Chemtex has invested approximately $200 million in the development of PROESA™. The process is designed to provide low-cost, high quality 2nd generation sugars readily convertible into bio-fuels and/or bio-chemicals. PROESA™ integrates an energy efficient, chemical-free biomass pretreatment operation and a novel viscosity reduction and enzymatic hydrolysis step. The unique configuration ensures limited formation of degradation products that could lower yield and inhibit (bio)catalyst performance. The technology is designed to guarantee flexible operations with multiple feedstocks and to maximize sugar recovery. Indeed, one of the features of PROESA™ is the opportunity to process a number of different biomass types ranging from energy crops (such as Arundo donax, fiber sorghum, etc.), agricultural residues (corn stover, wheat straw, etc.), woody biomass (eucalyptus and poplar) and industrial by-products (e.g. sugar cane bagasse) without the necessity to change hardware. Chemtex has engineered and constructed a 1 dry ton/day biomass processing pilot facility in Rivalta, Italy integrating all unit operations required to convert lignocellulosic biomass into fuels and/or chemicals. Chemtex has partnerships with three leading bioconversion companies, Genomatica, Codexis, and Gevo, to integrate PROESA™ with downstream processes to produce value-added chemicals. In addition Chemtex has completed the construction of one of the world’s first commercial scale cellulosic ethanol plants in Crescentino, Italy. This plant is designed to produce approximately 20 million gallons of ethanol from a combination of agricultural residues and energy crops and is currently being started up.
4:15 Biobased Chemical Project Finance Considerations
John May, Managing Director, Stern Brothers & Co.
Project Finance Fundamentals
• Current State of the Bank Market
• Typical Project Finance Structure
• Project Structure Mitigates Project Risk
• Project Capitalization
• Successful Financing Requires Systematic Approach
• At Financial Close
Project Finance Execution
• Sources and Uses
• Private Placement Memorandum
• Independent Engineer Report
• Timetable
• Project Finance Waterfall
• Case Study – Project Finance Credit Quality
Stern Brothers & Co – Alternative Energy Finance Group
• Our People
• Our Projects
4:40 Partnering as a Pathway to Success
Michael Rosenberg, Vice President, Business Development, OPX Biotechnologies
Development and commercialization of a new biobased or renewable chemical can be a daunting task for any company, but is particularly difficult for the small technology startup. To successfully go from the initial proof of concept to bench scale to demonstration scale and on to commercial scale requires significant expertise and understanding in not just microbiology and bioprocess engineering, but also chemical engineering, product development, marketing and sales, regulatory, distribution and large-scale construction and construction management just to name a few. While it is possible that a small technology startup can acquire these skills and expertise through organic growth, the quicker path is usually through strategic partnerships. This presentation will explore the different type of relationships that OPXBIO has used in developing its first products and the benefits of these relationships in moving its products to the commercial marketplace.
Panel Discussion: Funding Opportunities - What's Hot in Venture Capital?
Moderator: Mark Bunger, Research Director, Lux Research
5:05 Panelist: Mark Gudiksen, Principal, TPG Biotech
Panelist: Thomas Erickson, Co-President & Director, First Green Partners
Panelist: Erik Rutten, Senior Investment Manager, DSM Venturing

Topics to be discussed:
  • Business model alternatives, partnering, tolling, and scaling
  • License/partnering model versus own products
  • Late stage investments versus early stage investments
  • Breakthrough developments current or needed in:

- Algae production platform
- New crops/feedstock
- Catalytic chemistry with bio-based feedstock
- Cellulosic ethanol production

5:40 Networking Reception & Poster Session
Day 1 Day 2
Day 2 - Tuesday, September 17, 2013
7:30 Continental Breakfast
Moderator: Vonnie Estes, Managing Director, GranBio
KEYNOTE PRESENTATION
8:00 Global Trends in Commercial Scale up of Biobased Fuels and Chemicals

John P. Ranieri


Richard J. LaDuca

Global Business Director
DuPont Industrial Biosciences
Biology-based solutions offer us the opportunity to transform economies by creating new, high-performance bio-materials that use less energy to manufacture, are preferred by customers and are better for the long-term health of the economy and the environment. DuPont has lead the way in pioneering these biobased routes to traditional chemicals such as Bio-PDO™ (bio-based 1,3 propanediol), currently used in dozens of applications from personal care and cosmetic applications to deicing, carpeting and textiles. Since starting up a joint venture that today operates one of the largest renewable materials facilities in the world in Loudon, Tenn., in 2006, DuPont has continued to push boundaries and create market-driven disruptive technologies.

Now, on the cusp of commercializing a non-food, renewable feedstock route to biofuels with the construction of a $200+MM cellulosic ethanol facility in Iowa, DuPont is again leading the market in bringing biobased solutions online. Hear firsthand the challenges and global trends in building this new facility and new industry. Learn about the need for partnering across the value chain, both upstream and downstream to make the momentous changes needed to introduce entirely new supply chains to the world.
Consumer Products & Packaging Applications
Moderator: Vonnie Estes, Managing Director, GranBio
  FEATURED PRESENTATION
8:45 Biobased Evolution in Consumer Products
John P. Ranieri



Kaj Johnson

Green Chef
Method Products
Method makes environmentally friendly cleaning, laundry and personal care products. The role as a Green Chef is to bring together the very best environmental and human health solutions together with innovative applications to solve consumer needs. In this talk, Kaj will share experiences and opportunities to help change sustainability in business. It’s all part of The Sustainability Puzzle.

The Sustainability Puzzle:
• How we will succeed in changing sustainability?
• Themes and Opportunities
• Let’s be the Change
9:10 Partnership in Innovation Using Biobased Chemicals
Tom Fahlen, Associate Research Fellow, Advanced Technology, Clorox
The Clorox Company is committed to responsible product development and environmental stewardship. Working with an open innovation mind-set, we are interested in partnerships that can enable incorporation of bio-based materials in our products. With cost pressures on consumer packaged goods, we reason that the justification for bio-based chemistry in our products will come from novel benefits that are unique to the source and/or engineering of biomolecules for specific functions. We are interested in exploring bio-based packaging materials, surfactant systems, antimicrobial compounds, food additives, and other functional ingredients that may deliver unique benefits. This talk is intended to serve as a conversation starter on how we approach open innovation and where we see potential for mutually beneficial collaboration incorporating bio-based chemistry into Clorox products.
9:35 Bringing Novel Bio-Based Ingredients to the Cleaning and Homecare Market
John Monks, Vice President, Business Development, Rivertop Renewables
Rivertop Renewables has created a proprietary oxidation platform for the development and manufacture of novel bio-based products for a variety of end-uses and industries. First to market will be a range of unique detergent builder ingredients for application in automatic dish detergents under the RioseTM detergent builder brand name. At Rivertop we believe that in developing sustainable bio-based products and solutions we must also deliver novel products and technologies that address unmet needs in all of the industries that we serve. In the wake of the phase-out of phosphates builders, consumers are demanding a return to high performance products that are also greener and safer. The detergent and homecare market sector is responding by embracing new ingredient technologies such as RioseTM detergent builder.

This presentation will provide:
- Insight into Rivertop’s unique manufacturing technology and product platforms.
- A view on aligning bio-based technologies with real-world applications and unmet needs.
- The story behind RioseTM detergent builder application and performance in auto-dish detergent.
- Ideas for future innovation opportunities based on Rivertop’s technology platform.
10:00 Morning Networking Break
Trends & Challenges in Commercial Scale Up
Moderator: Kevin Gray, Vice President, Biobased Chemicals, Chemtex; Beta Renewables
10:30 Bio-based Paraxylene via Virent’s BioForming® Process
Randy Cortright, Executive Vice President, Founder & Chief Technology Officer, Virent
In conjunction with the Coca-Cola Company, Virent Inc. is developing and commercializing innovative and novel catalytic methods that convert biomass-derived oxygenates to paraxylene, a chemical intermediate required for the production of polyethylene terephalate (PET). If successful, Virent’s process would allow for the large scale generation of bio-based paraxylene which subsequently can be used to generate a 100% bio-based PET. The Coca-Cola Company as well as other brand owner would use this bio-based PET as a direct replacement material for a variety of packaging applications. In particular, the Coca-Cola Company would use this material for bottling. Not only would such a bottle be generated from bio-based materials, but the PET would also be recyclable.

Virent's BioForming® technology is able to produce renewable “drop-in” aromatics from a wide range of abundant biomass feedstocks, including non-food varieties. Virent’s patented platform technology utilizes catalysts and reactor systems similar to those found in standard petroleum oil refineries. Virent’s novel technology is not limited to any single type of sugar, unlike processes such as fermentation that rely on microorganisms and enzymes. By selecting different catalysts and processing conditions, various types of sugars, including mixed sugar streams and polysaccharides, can be reliably converted into the desired chemical intermediates.

Benefits of this talk include discussions of:
(1) developing relationships with brand owners;
(2) discovery and development of catalytic technology for generation of paraxylene from biomass; and
(3) challenges of a “start-up” company to bring a product to market.
10:55 Challenges and Successes in Commercial Scale Lactic Acid Production for Renewable Plastic, PLA
Pirkko Suominen, Assistant Vice President & Director Biotechnology Develoment, Cargill
Advances in metabolic engineering have impacted fermentation industry. In addition to early adaptation by pharmaceutical and enzyme industries, very large scale industrial fermentation processes utilize metabolically engineered microbes today. One such example is Cargill’s yeast based low pH lactic acid process, which was implemented in 2008 and has completely displaced the conventional bacterial process at Cargill Blair plant, and predicted costs savings are realized.

This presentation addresses challenges of traditional bacterial lactic acid fermentation and describes development of a yeast based low pH process. Scaling an industrial fermentation is often presented as a linear process with success achieved when the industrial scale tanks are reached, when in fact that is often when the true challenges begin. Multiple iterations of scale-up and scale-down are often required to yield a stable, high yield, economically viable fermentation. Assumptions made regarding strain stability and perceived challenges in scale-up are often inaccurate vs. those actually encountered at production scale. Although lactic acid is one of the oldest chemicals produced through fermentation with a vast literature and practical knowledge, a series of challenges were encountered when scaling this fermentation. Issues and mitigation strategies will be discussed for contamination, phage, by-products and raw material cost spikes. Solutions for these problems span the range from very traditional fermentation condition manipulation to cutting edge biotechnology solutions.

Cargill’s CB1 yeast platform has many characteristics required in cost effective, robust industrial fermentation processes. These include high yield and productivity, tolerance to low pH, ethanol, high temperature and common inhibitors in cellulosic hydrolysates. These properties make it a good choice as a biocatalyst for many biobased chemicals, including cellulosic ethanol. Examples of using the CB1 platform for industrial products will be given.
11:20 Commercial-Scale and Beyond: Next Steps for our Industry
William Baum, Executive Chairman & Chief Business Development Officer, Genomatica
For years, customers and analysts have been looking for true commercial-scale production, repeatability of processes, viable economics and usable product. In late 2012, over 5 million pounds of BDO was produced using Genomatica’s process technology in just five weeks. This is significant news for our industry as it is an achievement that benefits all – by boosting the confidence of customers, partners and investors and by providing a new ‘base camp’ for the industry.

This presentation will discuss the recent milestone and how it can accelerate the evolution of the chemical industry toward the production of more sustainable materials and products.

Benefits of Talk:
• Share ideas on what the industry needs to show in terms of repeatability, viable economics and usable product
• Discuss how to expand the global footprint of renewables-based chemicals and materials
• Summarize Genomatica’s recent milestones and discuss next steps for our industry
11:45 Scale-up in Brazil: Deploying Technology and Creating a Supply Chain
  Vonnie Estes, Managing Director, GranBio
  GranBio is a Brazilian company focusing on producing biofuels and biochemicals from second generation feedstocks. As a biotechnology company, GranBiodevelops and licenses proprietary technologies and strategic alliances to be scaled industrially in Brazil. Its second generation ethanol plant in Alagoas will start up in early 2014. With a $150 million investment, production capacity will be 22 million gallons per year. By 2020 the company will invest over $1.8B, build at least 10 plants to produce cellulosic ethanol and biochemicals and produce 265M (1B liters) gallons per year of biofuel.

Benefits of talk:
Overview of GranBio's focus, plans and progress
Bio-chemical value chain & GranBio's place
Discussion of developing relationships for technology partnership / deployment
[Short Oral Presentation]
12:10 Consumer Product Companies Driving Demand for Renewable Chemicals and Plastics
Brett Lund, Executive Vice President, General Counsel and Secretary, Gevo
Gevo’s proprietary technology platform is designed to manufacture isobutanol from multiple feedstocks. We use a combination of metabolic engineering and our patented GIFT® (Gevo integrated fermentation technology) system to produce this versatile chemical, which can be used as a drop-in additive to bio-plastic production processes, including the production of paraxylene and PET plastic. We hope to enable the production of a 100% renewable PET plastic, a goal shared by our business partners, particularly Coca-Cola and Toray, who are developing renewable alternative to conventional plastic.
[Short Oral Presentation]
12:20 High Value Renewable Feedstocks from Camelina for Industrial Applications
Jack Grushcow, Founder, President and Chief Executive Officer, Linnaeus Plant Sciences Inc.
Linnaeus Plant Sciences Inc. and DuPont Pioneer have teamed up to produce the next generation of renewable, high value industrial feedstocks in Camelina – a drought tolerant non-food oilseed crop that can be produced on marginal lands with low inputs. The collaboration has produced new patented GM varieties of Camelina with oil profiles optimized for industrial applications including polymers, lubricants and surfactants. Linnaeus is a leader in the development of Camelina and is currently marketing (Midastm) its elite variety with high yield and disease resistance. Trials of High Oleic Camelina lines, the first non-food source of this feedstock, are underway.

Benefits
1. Offers an overview of next generation renewable feedstocks derived from Camelina – a non-food drought tolerant oilseed.
2. Describes specific fatty acid profiles available for lubricant and polymer production derived from new lines of Camelina
3. Outlines production strategies and partnerships in place for large scale GM production of camelina lines.
4. Discusses Linnaeus’ patented process methods used in the production of fatty acid cuts optimized for lubricant and polymer production.
  [Short Oral Presentation]
12:30 Use of Patent Information for Breakthrough Innovation in Biofuels and Biomass Products: Case Studies from World's Leading Companies
  Samir Raiyani, Dolcera Corporation
  Thousands of patents and papers are published every year for the production of bio-fuels from biomass utilizing various concepts in biotechnology. Different pathways for fermentation using either synthetic or natural organisms are being explored at a frantic speed. New pathways can be potentially designed through a combination of knowledge obtained from the discoveries being made. Such pathways could be an integration of several small independent pathways that have been researched. Alternately, pathway innovation may involve synthesizing new organisms that integrate the functionalities of pathways already reported. In the context of the information deluge, there is a very strong need for organizations to establish a core information group. The role of the information group is to collaborate with scientists on an on-going basis. The organization structure should be such that information group plays a critical role at every stage of a research project. In this abstract, Dolcera will be sharing the best practices that scientists and researchers from leading organizations think on what succeeds and what does not. Casestudies from Dow AgroScience and Gevo would be shared.
12:40 Lunch Provided by GTC
Advantageous Feedstock for Biochemical Commercialization
Moderator: William Orts, Research Leader, Bioproduct Chemistry & Engineering, USDA
1:40 Key Success Factors for Cellulosic Bio-Refineries
Philippe Lavielle, Chief Executive Officer, Virdia
Virdia is the developer of the CASE™ process, one of the world’s leading cellulosic sugar platforms. It uses a series of proprietary acid/solvent extraction and purification technologies to produce high specification sugars and lignin for uses in nutrition, chemicals and energy. For instance, Virdia’s sugars are recognized as reliable intermediates for the production of polymer building blocks via fermentation and thermo-catalytic conversion. Virdia’s lignin is developed as a precursor to carbon fibers and graphite products, as well as a valuable intermediate for phenolic resins and flame-retardants.

The presentation will focus on Virdia’s efforts to commercialize the CASE™ process and identify the key factors of success for integrated cellulosic refineries.
2:05 Successful Production of Petro-Replacement Chemicals from Renewable Feedstocks
Arne Duss, Senior Vice President, Strategy & Corporate Development, Myriant
Most products used every day are manufactured using non-renewable feedstocks mainly from crude. These chemicals can be displaced with renewable, sustainable chemicals that are eco-friendly. Myriant Corporation is a global leader in the development and commercialization of high-performing, cost competitive bio-based chemicals produced using renewable sources of feedstocks. Myriant’s flagship bio-based chemical facility in Lake Providence, Louisiana, has a nameplate capacity of 30 million pounds of bio-succinic acid per year. Myriant is the first biochemical company to produce and commercialize bio-succinic acid from renewable feedstocks in North America.

Attendees will learn:
1. Challenges and opportunities along the pathway to commercialization of bio-based chemicals;
2. Value creation opportunities from bio-based chemicals
3. The importance of strategic partnerships along the value chain
2:30 Sorghum’s Increasing Value for Renewable Markets
Kenneth Davenport, Chief Technology Officer, Chromatin
The availability of renewable feedstock - beyond corn, sugarcane and trees – will become even more imperative as next-generation bio-processing technology for the bioenergy, biofuels, chemicals and materials market sectors comes on-line. Sorghum (S. bicolor and S. Sudanese), particularly grain sorghum, is used for almost 30% of ethanol production in the U. S. today.

Unlike many other proposed energy crops, planting seed production/processing and distribution channels, cropping systems and markets are well-established. Furthermore, as the world’s 5th largest cultivated grain crop, sorghum is known to growers throughout the world who plant >100 million acres per year.

One of the many attractive attributes of sorghum is not only its low input requirements such as water and fertilizer, but its resiliency to adverse environments. Because of its lower nutrient and water demand, sorghum can be grown on lands that are more marginal than those found in the U.S. corn belt.

Sorghum is a genetically diverse species and, as such, is an excellent source of starch, sugar and lignocelluloses. Given its molecular composition, it offers both similar and complementary sources of building blocks relative to corn and sugarcane.

Benefits:
• Familiarize the bio-based industry with sorghum as a currently available feedstock
• Familiarize the bio-based industry with sorghum genetics, biotech and agronomics
• Familiarize the bio-based industry with sorghum compositional characteristics
2:55 Securing the Upstream: Perspectives on Feedstock Planning
  Richard Hamilton, Chief Executive Officer, Ceres
At what price of oil can your technology compete? Mr. Hamilton will take a look at how oil prices influence the cost and availability of raw materials for biochemicals, and how agricultural technology and feedstock planning can help biochemical producers avoid getting squeezed by rising feedstock prices. He will also examine the lessons from Brazil’s success with bioenergy feedstocks, and their implications for scaling up production of energy crops and biochemicals in the U.S. and elsewhere.
3:20 Conference Concludes
Day 1 Day 2
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