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Day 1 Day 2
Day 1 - Thursday, September 18, 2014
7:00 Registration & Continental Breakfast
7:55 Welcome & Opening Remarks
Moderator: Aseem Sharma, Amyris

8:00 Bio-based Chemicals: BASF’s Perspective

Markus Pompejus
Vice President, White Biotechnology Research North America
In 2050, nine billion people will live on this planet. We are facing huge global challenges, in particular in the areas “resources, environment and climate,” “food and nutrition” and “quality of life.”

Chemistry as a key industry is a driving force for providing sustainable solutions for the challenges in all these areas. Sustainable solutions can only be achieved through innovation. This is why Research and Development has such enormous importance in BASF’s “We create chemistry” strategy.

BASF focuses on promising growth fields in defined industries whose progress is instrumental in creating intelligent chemistry. Cross-sectional technologies and interdisciplinary approaches are needed in order to develop solutions for these growth fields. An example of such a technology field within BASF is “White Biotechnology” or “Industrial Biotechnology”.

The purpose of White Biotechnology at BASF is to develop sustainable and intelligent solutions for our customers, including those in the food, health, pharmaceutical, crop protection and chemical industries. Microorganisms and enzymes are used in biotechnological processes in order to produce a wide range of products and to meet the worldwide demand for high-performance products such as vitamins, crop protection products, optically active chemicals and intermediates in BASF’s value-adding chain.

In addition to in-house activities in Europe and North-America, collaborations with academia and partnerships with technology leaders, such as Allylix, Cargill & Novozymes, Dyadic, Genomatica or Renmatix are important elements in BASF’s White Biotechnology activities. With the acquisition of Verenium, BASF strengthened its position in the development of enzymes for industrial applications.
Novel Technologies & Platforms in Biochemical Production
Moderator: Aseem Sharma, Amyris
8:45 Specialty Chemical Production from Natural Oils: Elevance Olefin Metathesis-Based Biorefinery

Steven Cohen
Director, Catalyst and Chemicals Technology
Elevance Renewable Sciences

Elevance uses olefin metathesis catalysis to produce high performance, cost-advantaged chemicals from renewable oils. The core catalyst technology is based on the work of Caltech Professor Robert H. Grubbs. Two of the technical breakthroughs that were required for commercialization of the technology are i) achieving high catalyst activity with commercially available natural oils, and ii) the development of a highly efficient process to produce olefins and novel fatty ester products. Equally important was the development of an innovative business model that promotes market entry. The technology was validated through the completion of several toll manufacturing campaigns and, in 2013, Elevance completed construction and began commercial production at a world-scale metathesis biorefinery in Gresik, Indonesia. Also in 2013, Elevance commercialized Inherent™ C18 diacid, a linear monomer and specialty chemical intermediate. The Elevance biorefinery process and biorefinery products will be discussed along with some of the market applications for the products.

Specialty Chemical Production from Natural Oils via Olefin Metathesis
- Elevance Renewable Sciences – Who we are
- What is Olefin Metathesis?
- Elevance Biorefinery Process and Products
- Examples of Markets Applications and Enhanced Product Performance

9:10 Carbon: The Final Frontier

Sean Simpson 
Chief Scientific Officer and Founder  
Increasing worldwide demand for biofuels from renewable feedstocks is driving the rapid development of technologies to produce low carbon fuels and chemicals.

LanzaTech’s novel gas-to-liquid technology has opened up vast new sources for making low-carbon chemicals and fuels that displace petroleum without the environmental concerns associated with crop- and land-based bioproducts. This flexible technology has the potential to disrupt the current highly centralized petroleum-based energy system by enabling regional production of low-cost, energy from local wastes and residues.

Current chemical production methods involve commodity raw materials (sugars, petroleum, natural gas) whose value can change dramatically over short periods of time. LanzaTech has identified and successfully demonstrated an alternative pathway that results in decoupling the production of commodity chemicals from commodity feedstocks. This means the fluctuations in the cost of raw materials and therefore chemical intermediates will be dampened substantially by introducing chemicals produced from waste gas streams. This will have a game changing impact on the chemical industry and it's supply chain - a trillion dollar industry shifting the way it thinks about commodity sourcing and supply.

- How carbon can be an opportunity not a liability
- Decoupling commodity chemicals from commodity feedstocks.
- The importance of strategic partnerships across the value change for commercialization
9:35 A Solar Platform for CO2-to-Chemicals Production

Sissi Liu
Director, Business Development
Joule Unlimited

This presentation will address the progress and potential of a solar-driven platform for the conversion of industrial waste CO2 into chemicals of interest. Unlike processes dependent on agricultural or algal biomass, this process depends only on the availability of sunlight, waste CO2, non-potable water and non-arable land. The platform applies engineered catalysts (cyanobacteria) to directly produce and secrete the molecules of interest as a product of photosynthetic metabolism, with no further processing required. Proof of concept has already been achieved for a number of high-value chemicals, and the platform is currently operating at demonstration scale with the production of ethanol.

10:00 Morning Networking Break
10:30 Scalable Production of Bio-Based Specialty Chemicals and Nylon Intermediates using Chemical Catalysis

Tom Boussie
Co-Founder, Vice President, Corporate Development
Rennovia is developing scalable, catalytic conversion processes for the production of high-value chemical products from renewable raw materials. Employing advanced catalysts and industrial chemical manufacturing technologies, Rennovia is focused on the production of bio-based chemical products at costs significantly advantaged over current petrochemical processes. Rennovia is advancing a suite of chemical products that include glucaric acid, adipic acid, 1,6-hexanediol, and hexamethylenediamine.

This presentation will describe Rennovia’s approach to bio-based chemicals production, and the current status of the products under development. We will also discuss the scale-up and commercialization strategy for each product, and outline potential strategic partnership opportunities.
10:55 PEF: A New Bio-based Plastic with Enhanced Performance. From Biomass to Packaging Solutions

Gert-Jan Gruter
Chief Technology Officer
Although for energy also other alternative sources such as solar, wind and geothermal exist, for materials the only alternative resource is biomass. While drop-ins (e.g. ethylene, p-Xylene) have obvious advantages, it can be questioned if hydrocarbons such as ethylene, propylene and p-xylene (C8; no oxygen) would be developed as monomers if we would not have had oil.

When changing from hydrocarbon fossil feedstock to carbohydrate biomass we should put more effort into developing new monomers that represent the functionality that is already present in biomass much better even though the market indroduction is much more difficult than with hydrocarbon drop-ins. Furan dixarboxylic Acid is an example of a ‘new’ monomer. New monomers will lead to new polymers with different properties which may be advantageous for certain applications. To progress on the development of PEF will be discussed.

An important topic for the bio-based economy is feedstock. Today all commercially available carbohydrates that can be used for chemical applications are sucrose or starch-based, so called ‘first generation’ feedstock. In the longer term, everyone agrees that ideally the carbohydrate feedstock for chemical and certainly fuel applications should be second generation or (hemi-) cellulose based. Avantium works with its partners to make this a reality.

- Pro’s and Con’ s, status and outlook of various feedstock options will be discussed.
- A new polyester is coming. What will be the benefits of PEF.
- PEF beyond bottles.
11:20 Separation and Purification, the Missing Link Between Biomass Deconstruction and Commercial

John Bhatt
Vice President, Industrial Biotech 
Bio-refineries face the challenge of valorizing all fractions obtained from the deconstruction of biomass by producing chemicals or commodities. Such bio-based products can be valorized as material additives (polyphenols from lignine), biofuel or chemicals (from sugar fractions). These sub-products differ in terms of physico-chemical characteristics as well as in added-value. To make sure they can integrate the end-user supply chain, it is necessary to improve their quality and meet industry specifications.

In the last decades, efforts have been put on fraction transformation and the search for industrial valorization routes. Less attention has been paid on the removal of impurities despite their impact on industrial manufacturing processes and the quality of end-products. The purification challenge is even greater because biomass hydrolysates strongly depend on the biomass variability and the cracking process choice.

Until recently, there was an important lack of industrial purification solutions to produce standardized bio-based products at specification and at cost. Novasep developed an important portfolio of purification technologies to support bio-industries in their efforts to valorize each fraction for further industrial transformation/applications. This presentation will highlight which technologies are the most suitable to overcome the different purification challenges that can be encountered from biomass cracking to value-added products.
11:45 Lunch on Your Own
Advantageous Feedstock for Biochemical Commercialization
Moderator: William Orts, USDA
1:00 Advanced Biofuels and Renewable Chemicals from Cellulosic Biomass

Kevin Gray
Vice President, Biobased Chemicals
Beta Renewables

Since 2006 Biochemtex has invested approximately $200 million in the development of the PROESA™ technology. The process is designed to provide low-cost, high quality second generation sugars readily convertible into bio-fuels and/or bio-chemicals. PROESA™ integrates an energy efficient, chemical-free biomass pretreatment operation and a novel viscosity reduction, enzymatic hydrolysis step. The unique configuration ensures limited formation of degradation products that could lower yield and inhibit (bio)catalyst performance. One of the features of PROESA™ is the opportunity to process a number of different biomass types ranging from energy crops, agricultural residues, woody biomass, and industrial by-products, without the necessity to change hardware. Biochemtex has engineered and constructed a 1 dry ton/day biomass processing pilot facility in Rivalta, Italy integrating all unit operations required to convert lignocellulosic biomass into fuels and/or chemicals. BetaRenewables, a joint venture between Biochemtex, TPG and Novozymes, was formed in 2011 to license the PROESA™ technology for the production of fuels and chemicals. BetaRenewables has partnerships with leading bioconversion companies, Genomatica, Codexis, and Gevo, to integrate PROESA™ with downstream processes to produce value-added chemicals. The PROESA™ technology is the basis for one of the world’s first commercial scale cellulosic ethanol plants located in Crescentino, Italy. This plant is designed to produce approximately 20 MM gallons of ethanol from a combination of agricultural residues and energy crops. Construction of a second plant in Brazil is expected to be completed in Q1 2014 while similar scale plants in North Carolina and California are in the design phase.

1:25 Natural, Premium Bio-­Materials: Guayule BioRubber - An Integrated BioRefinery

Leif Christoffersen
Director, Business Development
Crop science, bioprocessing and materials science are being applied for the development of non-GMO, plant-based biomaterials from guayule, a sustainable and industrial crop. Guayule is a highly productive chemical factory that does not compete against food or fiber crops and requires low inputs. These biomaterials are designed to replace traditional tropical Hevea or petroleum based rubber for consumer, industrial and medical markets, with the residual agricultural materials utilized as a feedstock for bioenergy. Yulex BioRubber has recently been commercialized in the form of the first plant-based wetsuit, an alternative to the traditional neoprene wetsuit.
1:50 A Balancing Act: A Seed Company’s Pursuit of Agricultural and Renewable Markets

Kenneth Davenport
Chief Technology Officer
The bio-energy, biofuels and bio-products industries have been challenged in recent years as evidenced by 1) an apparent abundance of natural gas and oil discoveries due to rapid deployment of “fracking” technology, 2) failure to meet targets set under RFS2, 3) failure of bio-products markets to materialize as anticipated, 4) marginal techno-economics of new conversion processes, 5) continued project financing hurdles, and 6) unfavorable political winds emanating from Washington D.C. with regard to renewable energy. Given these challenges, one might wonder what the future holds for not only these industries, but seed and feedstock companies that hope to find new market outlets in the renewable sectors.

While Chromatin has positioned itself to participate in renewable sectors, if and when they materialize, the focus of Chromatin remains on rapidly growing traditional and emerging agricultural markets. The synergies between agricultural markets and emerging renewable sectors will be presented as a means of illustrating how a growth company balances mid- and long-term opportunities in renewable sectors with opportunities (e.g., increasing market share, revenue and profitability) in agricultural markets.

- A realistic look at where renewable sectors stand today and where they may be headed.
- A realistic look at where agricultural markets stand today and where they may be headed.
- Insight into the interplay between renewable sectors and traditional agricultural markets.
- An illustration of how a growth company successfully pivots with changing market dynamics.
Strategic Partnerships
Moderator: William Orts, USDA

2:15 The Bridge to Bio Based Realities-One Partnership at a Time

Dale Steichen
Vice President, Director Business Development, Specialty Chemicals
For a large company, moving to an enhanced bio based raw material supply requires a clear strategy, agreed to by the Board, and dedicated personnel to drive the strategy. AkzoNobel currently uses significant volumes of bio based raw materials with ambitions to increase the biobased content of its products. A bio based materials strategy for the company was developed and the decision was taken to leverage market innovations via partnerships as one of the key vehicles of implementation versus in house developments. The economic realities were well understood and identifying technologies that are cost competitive versus current raw materials is a critical success factor.

Working with partners to create an alternative raw material supply base requires patience and a constant focus on win-win opportunities. It is a critical to identify technologies that when implemented, will create sufficient value for both partners. When mutually profitable technologies are identified, the discussions simplify and agreements, even on complicated subjects such as IP ownership, can be reached. The trip is not short but the destination is worth the journey.
3:00 Afternoon Networking Break
3:30 Strategies for Producing and Using Biobased Chemicals

William Baum
Board Member
Commercial technology is starting to be available for the biobased production of major, high-volume basic and intermediate chemicals. A good example is Genomatica’s GENO BDO™ process for the production of 1,4-butanediol (BDO), which has a market of over 1.6 million metric tons per year, and which has been licensed by BASF and Novamont. Two important implications are that chemical producers are beginning to have practical, economic alternatives to petroleum-based processes – for the chemicals they already produce – and that chemical users in numerous value chains are beginning to have a realistic way to increase the biobased content of products they already make, without changing their characteristics or their production process.

This presentation will summarize key issues for producers and users as they build their strategy for biobased chemicals. It draws from Genomatica’s experience working with numerous value chain partners for biobased BDO, as well as with strategic partners ENI/Versalis and Braskem in developing a process for biobased butadiene.
3:55 National Laboratories as a Strategic Partner

Richard Bolin
Manager, Partnership Development Group
National Bioenergy Center, National Renewable Energy Laboratory
  “I am from the government and I am here to help you.”  Most of us have heard the line and chuckled remembering the times when the government has tried to “help”. Strategic partnering with a national lab is an avenue for getting “help” from the government which benefits both parties. The partnership can leverage decades of public investment in capabilities, facilities, and expertise to solve a problem, innovate, or commercialize nascent technologies.      

The presentation will introduce you to the DOE national labs that have major research programs in biofuels and biobased products, examples of strategic partnerships, and recent DOE initiatives focusing on enhancing the technology to market mission. 
Panel Discussion: Strategic Partnerships
Moderator: Aseem Sharma, Amyris


Mark Jones
Executive External Strategy and Communications Fellow
The Dow Chemical Company

Dale Steichen
Vice President, Director Business Development, Specialty Chemicals

William Baum
Board Member
  [Oral Presentation from Submitted Abstract]
5:10 A Novel Transformational Process Replacing Dilute Acid Pretreatment with Deacetylation and Mechanical (Disc) Refining for the Conversion of Renewable Biomass to Lower Cost Sugars

Xiaowen Chen
National Renewable Energy Laboratory
  The deconstruction of renewable biomass feedstocks into soluble at low cost is a critical component of the biochemical conversion of biomass to fuels and chemicals. Providing low cost high concentration sugar syrups with low levels of chemicals, toxic inhibitors and contaminants, at high process yields is essential for biochemical platform processes. In this work, we utilize a new, possibly transformational process consisting of deacetylation followed by disc refining (DDR) for the conversion of renewable biomass to low cost sugars at high yields and at high concentrations without a conventional chemical pretreatment step. The new process features a low temperature (80°C) dilute alkaline (40kg NaOH /ODMT corn stover) deacetylation step followed by disc refining under modest energy consumptions. The proposed process was demonstrated using a commercial scale Andritz double disc refiner. Deacetylated corn stover is refined at varied specific energy ranged from 128kWh to 468kWh per oven dried tonne of corn stover, resulting in monomeric glucose and xylose yield of 82 to 90% and 75~82%, respectively, after enzymatic hydrolysis at process-relevant solids (15 and 20wt% total solids) and enzyme loadings (22.5mg enzyme protein per gram of cellulose). High process sugar conversions were achieved, yielding high concentrations of monomeric sugars that approaching 150 g/L, (total (monomeric + oligomeric) sugars >170g/L). Produced sugar syrups also possessed low concentrations of known fermentation inhibitors; furfural and HMF levels were non-detectable and acetic acid was below 0.3 g/L. Together, these results indicate that this process is an extremely promising development for the nascent cellulosic biofuels industry.
  [Oral Presentation from Submitted Abstract]
5:20 Rigid Biobased Building Blocks from Sugar Beet

Robert Nolles
Cosun Biobased Products
  In 2050 nine billion people will live on our planet. We are facing huge challenges in the areas of resources, environment, nutrition and quality of life. Sustainable chemistry will be key in creating solutions for these challenges. Through a smart biorefinery process, using biomass that is not suited for human consumption, Cosun is creating a number of rigid cyclic building blocks that are suitable for various applications within the chemical industry. GalX1 en GalX2 are two new bicyclic rigid biobased di-acids that can be used to develop biobased polymers for applications in household appliances, automotive, packaging, coatings and resins. GalXol is a bicyclic rigid diol suitable for the same applications. FDCA is a more well-known rigid building block that is being used to manufacture the biopolymer PEF. It has received a lot of attention over the recent years. Cosun has developed its own route based on non-edible sugars. From the same natural source Betawell® special sugars and Betafib® cellulosic fibers are produced. These products find their way in detergents, personal care and cosmetic products, health food, flavors, etc.
  [Oral Presentation from Submitted Abstract]
5:30 Bio-based Innovations and Platform Developments from the Engineering Research Center for Biorenewable Chemicals (CBiRC)

Peter Keeling
Center for Biorenewable Chemicals
  CBiRC is developing renewable chemical platforms from bio-based innovations and new ventures utilizing tools, components and materials being explored by the Center. Core knowhow and technologies include bioengineering of fatty acid and polyketide biochemistry in microorganisms, as well as an innovative and complimentary portfolio of developments in chemical catalysis. By combining biocatalysis and chemical catalysis CBiRC creates new knowhow and powerful technologies that have the potential to nurture a sustainable bio-based chemical industry. CBiRC believes the existing petrochemical supply chain can be transformed with key foundational intermediates that deliver an array of drop-in chemistry or similar functionality to existing fossil-carbon-based chemicals. Here we will describe our progress towards creating an advanced manufacturing system with new platform molecules for biobased chemicals.
5:40 Networking Reception and Poster Session
Day 1 Day 2
Day 2 - Friday, September 19, 2014
7:30 Continental Breakfast
Moderator: Aseem Sharma, Amyris

8:00 Practical Experiences in Bio-based Commercialization in Specialty and Commodity Chemicals

Frank Pacholec
Vice President, Research and Development & Corporate Sustainability Officer
Stepan Company
The intent of this presentation is to examine the current practicalities of successfully incorporating bio-renewable feedstocks into specialty and commodity chemical products. Recent advances in bio- engineering, process technology, and bio-renewable feedstocks, coupled with an environment of volatile raw material costs and emphasis on sustainability, has led to a flurry of technical and commercial activity. Stepan Company continues to be actively involved in the pursuit of commercializing bio-based chemicals across a wide range of markets and applications, with a primary focus on surfactant and polyol technology. Learnings from both successful and unsuccessful recent projects and programs, primarily in consumer products applications are presented. Ongoing requirements for successful commercialization in specialty and commodity chemical applications across a range of markets are reviewed, including preferred types of collaborations and partnerships, as well as cost/performance, intellectual property, regulatory, and market launch considerations. The current capabilities of feedstock sources and transformation technologies to meet requirements are discussed. A glimpse into technology and supply chain developments that are required to expand the incorporation of bio-renewable feedstocks into chemical applications beyond those feasible today, along with a projected realistic timeline will be offered.
Panel Discussion: Funding Opportunities
Moderator: Aseem Sharma, Amyris


John May
Managing Director, Co-Head Alternative Energy Group
Stern Brothers & Co.

Pulakesh Mukherjee
BASF Ventures

Pavel Molchanov
Senior Vice President & Equity Research Analyst
Raymond James & Associates
Panel Discussion: The Role of Government in Commercializing Biochemicals
Moderator: Richard Bolin, National Renewable Energy Laboratory


Kevin Craig
Program Manager, Bioenergy Conversion technologies
U.S. Department of Energy

William Orts
Research Leader, Bioproduct Chemistry & Engineering
U.S. Department of Agriculture

Valri Lightner
Assistant Director, Technical Division at Loan Program
U.S. Department of Energy
10:15 Morning Networking Break
End User Applications & Consumer Products
Moderator: Ross Eppler, Amyris

Ross Eppler
Associate Director, Technical Product Management, Performance Materials
  Amyris is an integrated renewable products company focused on providing sustainable alternatives to a broad range of petroleum-sourced products. Amyris uses its industrial synthetic biology platform to convert plant sugars into a variety of molecules -- flexible building blocks that can be used in a wide range of products.  One of its lead compounds is the branched hydrocarbon trans-b-farnesene (Biofene) which is currently in commercial production in Brazil.  Biofene is a unique product that can be chemically transformed into a variety of applications in the cosmetics, polymer, fuels, and specialty fluids sectors.  Amyris is introducing a new USDA certified, low vapor pressure (LVP) renewable solvent for the household, institutional, and industrial cleaning sector.  The material demonstrates improved performance over existing LVP products, while maintaining an enhanced environmental, health, and safety profile.
11:10 Sustainable Wins- How’s it going? What’s Next?

Kaj Johnson
Green Chef
Method Products
As an industry, we are probably teenagers in sustainability. We’ve made a lot of mistakes, learned some important lessons, done some great things and have a huge amount of opportunities and growth in front of us.

Reflection time: Where have we come from? What have we learned? What opportunities lie ahead to make sustainability an even larger part of our business DNA and become truly remarkable?

- Past Wins
- Present Focus
- Points Future Value
11:35 Lunch Provided by GTCbio
1:30 Conference Concludes
Day 1 Day 2

5th Biobased Chemicals Commercialization & Partnering Conference Agenda