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European Pharma Summit

2017-11-182017-10-162017-09-16
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MENTORS
Margaret Frame

Margaret Frame
Scientific Director, Cancer Research UK Edinburgh Centre
The University of Edinburgh
Margaret Frame
Scientific Director, Cancer Research UK Edinburgh Centre
The University of Edinburgh
 
About Mentor:

Margaret Frame is a research scientist with interests in novel cancer mechanisms, as evidenced by deep biology, imaging and new approaches to drug discovery and cancer therapeutics – work that has been funded by five successive CRUK (or predecessor charity) Programme grants and more recently also by an ERC Advanced Investigator Grant. From 2002-2007, Margaret was Deputy Director of the core funded CRUK Beatson Institute for Cancer Research in Glasgow, after which she moved to the University of Edinburgh (UoE). Currently she is Professor of Cancer Research, co-director of the CRUK Edinburgh Centre and Director of the MRC-Institute of Genetics and Molecular Medicine (IGMM). Margaret is very active in supporting the scientific careers of early- and mid-stage researchers, both clinical and non-clinical, an interest that stems from her time as Chairman of the CRUK New Investigator Panel and from her own experiences when building a research career during the ‘young family’ years. As Director of the IGMM, Margaret also intends to promote a strong translational agenda with innovative twists, including new approaches to biology-led drug discovery and translation of genomics to the NHS. In regard of personal achievements, Margaret was awarded the Tenovus Medal in 1999, and was elected a Fellow of the Royal Society of Edinburgh in 2002, an EMBO Member in 2007 and a Fellow of the Academy of Medical Sciences in 2009. Very recently, she was delighted to be awarded the Chancellor’s prize for Research - presented by HRH The Princess Royal (the Chancellor of the University of Edinburgh). In January 2016, she took up the role as President of the British Association for Cancer Research.

Michael Hann

Michael Hann
GSK Senior Fellow & Director, Drug Design & Selection
GlaxoSmithKline
Michael Hann
GSK Senior Fellow & Director, Drug Design & Selection
GlaxoSmithKline
 
About Mentor:

Since completing his PhD in organic chemistry in 1980, Mike has worked in Pharma R&D initially as a medicinal chemist and then as a computational chemist. He joined Glaxo in 1986 and was responsible for helping initially build and then lead the UK computational chemistry department. More recently he led the biophysics and protein crystallography activities including developing fragments theory and practice in lead identification. His current role is in looking at new ways to enhance our discovery approaches, reducing attrition and promoting scientific excellence across the GSK R&D sites. A particular current interest is in understanding drug distribution at cellular and subcellular resolution. Mike is a GSK Senior Fellow and an Adjunct Professor in the chemistry department at Imperial College London.

Michael A. Mancini

Michael A. Mancini
Professor, Molecular and Cellular Biology
Baylor College of Medicine
Michael A. Mancini
Professor, Molecular and Cellular Biology
Baylor College of Medicine
 
About Mentor:

The Mancini lab focuses upon single cell analysis of steroid receptor functions, primarily estrogen and androgen receptors (ER, AR), and attendant coregulators. Our HCA/HCS-based projects explore cell signaling, endocrine disrupting chemicals and epigenetics at the single cell level in engineered and native cultured cells.

Neil McDonald

Neil McDonald
Group Leader, Signalling and Structural Biology
Francis Crick Institute
Neil McDonald
Group Leader, Signalling and Structural Biology
Francis Crick Institute
 
About Mentor:

Neil joined the Cancer Research UK London Research Institute as an independent group leader in 1994. He previously carried out postdoctoral research at Columbia University. He moved in 2016 to the new Francis Crick Institute as a Senior Scientist and has also held a chair at Birkbeck College since 2006. His research interests are focused on molecular mechanisms that control the assembly and activation of growth factor signaling complexes and their associated catalytic functions. He has contributed to several CR-UK and Wellcome Trust-funded drug discovery programs, including one that has delivered a first-in-class, pre-clinical candidate against a known cancer target. 

Ingo Mugge

Ingo Mugge
Senior Research Fellow
Alkermes
Ingo Mugge
Senior Research Fellow
Alkermes
 
About Mentor:

Dr. Ingo Mügge is a Senior Research Fellow at Alkermes, Inc. In this role he leads the Modeling & Informatics efforts in the Discovery department contributing to the advancement of early drug discovery projects. Dr. Mügge has more than 20 years of experience working in the pharmaceutical industry in leadership positions at Bayer Healthcare, Boehringer Ingelheim, and Alkermes focusing on research in CNS, immunology, and cardio-metabolic related diseases. His research interests include in silico driven drug design techniques such as virtual screening, structure-based drug design, and predictive modeling. He has published more than 60 scientific papers and book chapters, co-organized scientific conferences, and serves on the scientific advisory board of Molecular Informatics. Dr. Mügge holds a European diploma degree in physics from the Humboldt University Berlin and a doctorate degree in computational chemistry from the Free University Berlin. Postdoctoral appointments allowed him to work with Yvonne Martin at Abbott Laboratories and Arieh Warshel at the University of Southern California.

Sereina Riniker

Sereina Riniker
Professor, Physical Chemistry
ETH Zurich
Sereina Riniker
Professor, Physical Chemistry
ETH Zurich
 
About Mentor:

Sereina Riniker has been an Assistant Professor (with tenure track) of Computational Chemistry at the Laboratory of Physical Chemistry since June 2014.

She was born in Switzerland in 1985.

In 2008, she completed her master’s degree in chemistry at ETH Zurich, with a research project at the Autonomous University of Barcelona with Prof. Xavier Daura. After an internship in the research department of Givaudan AG and a research stay in the group of Prof. Berend Smit at UC Berkeley, she returned in 2009 to ETH Zurich to obtain a PhD in molecular dynamics simulations with Prof. Wilfred van Gunsteren.

From 2012 to 2014, she held a postdoctoral position in cheminformatics under the supervision of Dr. Gregory Landrum at the Novartis Institutes for BioMedical Research in Basel and Cambridge, Massachusetts.