Johanna Heideker



Johanna Heideker

Dr. Heideker received her PhD in 2012 from The Scripps Research Institute, La Jolla, CA, studying the functions of a SUMO-targeted ubiquitin ligase in DNA repair and genome maintenance in the laboratory of Michael (Nick) Boddy. From there she joined Ingrid E. Wertz’ lab at Genentech as a Postdoctoral researcher, where she set out to explore novel roles of deubiquitinases (DUBs) in human disease. During her time at Genentech in collaboration with the Proteomics and Biostatistics departments she build a novel quantitative platform to measure deubiquitinase activity in a semi-native environment that can be used to both identify new cellular modes of DUB regulation as well as aid the development of compounds targeting DUB activity. Her assay is now being used across GNE departments to aid the study of DUBs and support drug discovery efforts targeting the ubiquitin-proteasome system.

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