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Rama K. Mallampalli

UPMC Endowed Professor and Division Chief, Pulmonary, Allergy, and Critical Care Medicine

University of Pittsburgh

 
Rama K. Mallampalli

Dr. Mallampalli is a UPMC Endowed Professor and Division Chief of Pulmonary Allergy, and Critical Care Medicine at the University of Pittsburgh School of Medicine. He work is internationally recognized in the pathogenesis of sepsis and pneumonia as it relates to acute lung injury (ALI). His research has discovered a unique model for the molecular behavior of ubiquitin E3 ligase subunits belonging to the Skp-Cullin1-F box (SCF) family that control inflammation. Dr. Mallampalli’s laboratory designed, synthesized, and tested a new genus of ubiquitin E3 ligase (F box) inhibitors that modulate proteolysis thereby inhibiting inflammation in preclinical models of ALI and multi-organ failure.

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