Dr. Rissman’s work at UCSD is split into several parts that are balanced relatively equally. The goal of his basic science research is to discover novel biomarkers for neurodegenerative diseases with a specific focus on blood-based biomarkers. Of primary interest is the study of the biomarker utility and pathologic potential of neuronally-derived exosomes. Dr. Rissman’s in vivo work is focused on the contribution of stress and changes in stress signaling intermediates in Alzheimer’s disease neuropathology and the discovery of compounds that impact the corticotropin-releasing factor system in Alzheimer’s Disease.
In addition to the research program, Dr. Rissman is the Director for the Alzheimer’s Disease Cooperative Study (ADCS) Biomarker Core and the Neuropathology/Brain Bank for the Alzheimer’s Disease Research Center (ADRC) at UCSD. Both cores are comprised by wet laboratories and a biospecimen banks.
Dr. Rissman is also the PI of UCSD’s Neuroplasticity of Aging Training Grant (T32) and teach graduate classes in the Neurobiology of Disease.