Stephen J. Kolb is a physician-scientist at the Ohio State University Wexner Medical Center. He is an Associate Professor in the Department of Neurology and Department of Biological Chemistry & Pharmacology whose laboratory is focused upon motor neuron biology and disease pathogenesis. Clinically, he is Director of the OSU ALS/MND Clinic and Translational Research Program. Dr. Kolb obtained a BA in Biochemistry at the University of Texas at Austin. He earned his MD and PhD degrees at the University of Texas Health Science Center in Houston, where he completed graduate studies in Neuroscience in the laboratory of Dr. Neal Waxham. He then completed a Medicine Internship and Neurology Residency at the University of Pennsylvania. It was during this time that he became interested in motor neuron disease pathogenesis and began his involvement in spinal muscular atrophy research as a postdoctoral fellow in the laboratory of Dr. Gideon Dreyfuss at Penn. In his own lab, Dr. Kolb has continued his involvement in SMA research on basic, translational and clinical levels of inquiry in a fertile and collaborative environment at Ohio State. Most recently, he led the premier clinical study of the NINDS-sponsored NeuroNEXT Clinical Trial Network that has provided important natural history data for clinical trials in infants with SMA.